Overlapping functions of myosin-I isoforms?
نویسندگان
چکیده
منابع مشابه
Overlapping functions of myosin-I isoforms?
S INCE the discovery of myosin-I (MI) 1 in Acanthamoeba (32), DNA cloning and/or biochemical purification have established the presence of multiple MI isoforms in nearly every eukaryotic cell examined. Despite intensive study, the physiological role of these actin-based, molecular motors has remained a mystery, in large part, because cells express several isoforms of MI with similar biochemical...
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S INCE the discovery of myosin-I (MI) 1 in Acanthamoeba (32), DNA cloning and/or biochemical purification have established the presence of multiple MI isoforms in nearly every eukaryotic cell examined. Despite intensive study, the physiological role of these actin-based, molecular motors has remained a mystery, in large part, because cells express several isoforms of MI with similar biochemical...
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Acanthamoeba myosins IA and IB were localized by immunofluorescence and immunoelectron microscopy in vegetative and phagocytosing cells and the total cell contents of myosins IA, IB, and IC were quantified by immunoprecipitation. The quantitative distributions of the three myosin I isoforms were then calculated from these data and the previously determined localization of myosin IC. Myosin IA o...
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Dictyostelium cells that lack the myoB isoform were previously shown to exhibit reduced efficiencies of phagocytosis and chemotactic aggregation ("streaming") and to crawl at about half the speed of wild-type cells. Of the four other Dictyostelium myosin I isoforms identified to date, myoC and myoD are the most similar to myoB in terms of tail domain sequence. Furthermore, we show here that myo...
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The Drosophila melanogaster GAGA factor (encoded by the Trithorax-like [Trl] gene) is required for correct chromatin architecture at diverse chromosomal sites. The Trl gene encodes two alternatively spliced isoforms of the GAGA factor (GAGA-519 and GAGA-581) that are identical except for the length and sequence of the C-terminal glutamine-rich (Q) domain. In vitro and tissue culture experiments...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1996
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.133.2.221